Welcome back to SRS Nutri-Know! In our first episode, we discussed the reasons behind the potential ban or restriction of NMN and its anti-aging benefits.
In 2013, a research team led by Harvard Medical School professor David Sinclair revealed the potential of NMN, a precursor to the NAD+ coenzyme, in reversing aging and extending lifespan. This breakthrough quickly turned NMN into a "new star" in the anti-aging field. However, whether NMN will face a ban remains uncertain, and we await official announcements from the authorities.
As the anti-aging industry undergoes an innovation wave, what other promising anti-aging ingredients are emerging? How do their mechanisms differ, and can they lead the market in anti-aging solutions? Let’s explore:
1. Longevity Vitamin: Ergothioneine (EGT)
Ergothioneine, a naturally occurring amino acid, was first isolated in 1909 by Charles Tanret. In 1911, Barger and Ewins determined its structure and identified it as a derivative of histidine betaine.
Research indicates that ergothioneine is linked to healthy aging and combating age-related diseases. Bruce Ames, a biochemistry and molecular biology emeritus professor at the University of California, Berkeley, calls it a "longevity vitamin." Its anti-aging mechanisms include:
1.Antioxidant Properties: EGT effectively scavenges free radicals, reducing cellular damage.
2.Genomic Stability: EGT absorbs UV light and repairs UV-induced DNA damage.
3.Epigenetic Modifications: EGT may influence DNA and RNA methylation and histone modifications by affecting cellular redox states.
4.Sirtuin Pathway Regulation: EGT interacts with NAD+-dependent deacetylases, protecting endothelial cells from high glucose-induced aging and upregulating SIRT1 and SIRT6.
Ergothioneine can be sourced from mushrooms, chemical synthesis, and synthetic biology. Synthetic biology fermentation is currently popular. Since 2014, ergothioneine has been included in the Chinese "List of Used Cosmetic Ingredients," and its exceptional antioxidant properties make it a key ingredient in skincare products. It is also applying for new food ingredient status, suggesting its cross-industry application potential in food and functional foods.
2. New NAD+ Precursor: Trigonelline
Trigonelline, a pyridine alkaloid, primarily comes from fenugreek and coffee beans. It is also found in soybeans, alfalfa, and mulberry leaves.
Among NAD+ precursors like NMN, NR, NA, Trp, and Nam, trigonelline is a recent discovery. It can increase NAD+ levels by about 50% and maintain high serum concentrations for up to 72 hours. This finding offers an alternative to NMN in anti-aging.
Trigonelline boosts NAD+ levels, enhances mitochondrial activity, and supports aging improvement. Specifically, it promotes NAD+ biosynthesis via the niacin phosphoribosyltransferase/Preiss-Handler pathway, enhancing mitochondrial oxidative phosphorylation and activating the sirtuin pathway. This affects cellular metabolism, DNA repair, and cell cycles.
Trigonelline supplementation can be achieved through diet, microbial synthesis, and metabolic regulation, although market products are currently limited. Nootropicsdepot offers fenugreek extract capsules (500 mg/bottle), containing 3% trigonelline and 1% diosgenin, which support mood, fitness, and metabolic functions.
Stay tuned for our next episode, where we will dive into more groundbreaking ingredients like Spermidine, Quercetin, and Alpha-Lipoic Acid, each with unique mechanisms that could revolutionize the anti-aging market.
SRS Nutrition Express specializes in the field of nutritional ingredients. We invite you to discuss industry developments and market supply situations with us. Together, let's shape the future of anti-aging.
#AntiAging #Longevity #HealthInnovation #NutritionalScience #SRSNutriKnow
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Post time: Jul-04-2024
