Welcome back to SRS Nutri-Know! In our previous episode, we explored the emerging ingredients Ergothioneine and Trigonelline, which have shown great potential in the anti-aging market. As the quest for longevity continues, researchers and companies are constantly discovering and developing new compounds to combat the effects of aging. In this episode, we will delve into more groundbreaking ingredients that could lead the future of anti-aging.
3. Autophagy Inducer: Spermidine
Spermidine, discovered in 1678 by Dutch scientist Antonie van Leeuwenhoek, was structurally identified in 1924 by Rosenheim. As a polyamine, spermidine plays a crucial role in cell renewal and growth.
Spermidine, found abundantly in mammals and easily absorbed from foods like wheat germ, soybeans, aged cheese, and mushrooms, promotes autophagy—a cellular recycling process. Autophagy dysfunction increases oxidative damage and accelerates aging, disrupting protein homeostasis and reducing cellular energy production.
Spermidine supplementation can reverse age-related changes, driving demand for spermidine dietary supplements. Spermidine LIFE Original 365+ contains 2 mg spermidine per capsule, along with zinc and thiamine, supporting cellular renewal and overall health.
4. Free Radical Scavenger: Quercetin
Quercetin, named after the oak tree (Quercus), has been used since 1857. It is a natural polar auxin transport inhibitor and a flavonol, found in apples, berries, tomatoes, grapes, onions, and medicinal plants like ginkgo biloba.
Quercetin’s strong antioxidant capabilities are demonstrated in recent studies. Dasatinib combined with quercetin (D+Q) selectively clears senescent dermal fibroblasts and inhibits the senescence-associated secretory phenotype (SASP). Quercetin can induce the death of senescent human umbilical vein endothelial cells (HUVECs).
In 2010, quercetin received GRAS certification from the FDA, allowing its use in beverages, cereals, pasta, processed fruits, and fruit juices, up to 500 mg per serving. In Japan and Korea, quercetin is used as a food additive. In China, quercetin is not yet approved for general or health foods, but dihydroquercetin has been approved as a new food ingredient. Pure Encapsulations Quercetin, containing 500 mg per serving, promotes immune, cellular, and cardiovascular health.
5. Universal Antioxidant: Alpha-Lipoic Acid (ALA)
Alpha-lipoic acid, a powerful intracellular antioxidant, is rapidly absorbed and utilized by cells. It transforms into dihydrolipoic acid, which, along with ALA, scavenges reactive oxygen and nitrogen species, chelates metal ions, and regenerates endogenous antioxidants like glutathione, vitamin C, and vitamin E.
ALA’s cyclical regenerative action makes it a "reducer’s reducer." Unlike NAD+, ALA serves as a cofactor in mitochondrial enzymatic reactions, aiding cellular energy metabolism and slowing mitochondrial aging by preventing mutagenic oxidants' release.
ALA is widely used in medicine, dietary supplements, and cosmetics. In the West, it is commonly found in dietary supplements, whereas in China, it is primarily used in pharmaceuticals. The FOR BECARDE ONE dietary supplement features ALA capsules that support the reduction of CoQ10, glutathione, vitamin E, and vitamin C.
These emerging ingredients demonstrate diverse mechanisms and potential in the anti-aging market, paving the way for future innovations and solutions.
SRS Nutrition Express specializes in the field of nutritional ingredients. We invite you to discuss industry developments and market supply situations with us. Together, let's shape the future of anti-aging.
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Post time: Jul-05-2024
